DCPDC-Mediated Facile Amide-Bond Formation of Non-Nucleophilic and Hindered Amines

Synlett 2026

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Authors: Atanu Patra, Mohana Rao Vippila, Mahua Baishnab, Balaji Deva, Manivannan Muthukumar, Arvind Mathur, Richland W. Tester
DOI: 10.1055/a-2823-3166
Cited by: 0
References: 46

Abstract

Abstract A facile synthesis of amide bond formation involving non-nucleophilic and hindered amines is reported. DCPDC found itself to be an economical reagent for amide synthesis by activation of carboxylic acid. The reaction proceeds via diester intermediate formed by reaction between carboxylic acid and DCPDC. The approach presents a broad range of substrate scopes with 39 examples given. Notably, the reaction works equally well on scale up providing the desired product in excellent yield without any purification. More interestingly, our preliminary results indicated retention of configuration for chiral amines and acids.

Fields of Study & Subjects

Chemical Synthesis and Analysis Chemical Synthesis and Reactions Advanced Synthetic Organic Chemistry

Publication details

Journal / source
Synlett
Volume
37
Issue
09
Pages
1074–1080
Publication date
1 March 2026
Language
EN