Synthesis of Various New 2-Sulfonyl-Imine-Benzazoles via Heteroaryl C–H Activation Reactions of Benzo(thiazole-oxazole-imidazoles), Isocyanides, and Sulfinate Salts
Abstract
Abstract A copper-catalyzed, one-pot, three-component C–H activation reaction of isocyanides, sulfinate salts, and benzothiazole, benzoxazole, or benzimidazole has been developed for the preparation a series of novel functionalized benzazoles bearing a sulfonyl-imine skeleton. This method provides an efficient route to form novel functionalized benzazole derivatives from simple and affordable starting materials under mild reaction conditions in moderate to good yields. Finally, by employing this method, 15 new compounds were synthesized and characterized simply, rapidly, and efficiently (76–92%).
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Sulfur-Based Synthesis Techniques
Cyclopropane Reaction Mechanisms
Publication details
- Journal / source
- SynOpen
- Publisher
- Georg Thieme Verlag KG
- Volume
- 10
- Issue
- 03
- Pages
- 190–194
- Publication date
- 1 July 2026
- Language
- EN