Selectfluor-mediated Regioselective Oxidative Fluorination of Indole Derivatives
Abstract
Abstract The development of strategies for oxidative fluorination represents an important avenue in the synthesis of valuable fluorine-containing compounds. A simple and regioselective methodology has been developed for the synthesis of 3,7-difluorinated oxindole derivatives from 3-substituted indoles in a Selectfluor™-mediated process in 15–71% yield. The reaction proceeds under mild, metal-free conditions with broad substrate scope and functional group tolerance, including electron-donating and electron-withdrawing groups on the indole ring.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Catalytic C–H Functionalization Methods
Oxidative Organic Chemistry Reactions
Publication details
- Journal / source
- Synthesis
- Volume
- 58
- Issue
- 10
- Pages
- 1165–1170
- Publication date
- 15 March 2026
- Language
- EN