Recent Advances in Persulfuranyl Transfer Reagents
Abstract
Abstract The pentafluorosulfanyl (SF5) group has emerged as an attractive motif in drug design, yet access to SF5-containing molecules was long based on toxic or gaseous reagents with limited practicality. In this review, we summarize recent advances in novel SF5 transfer reagents, with emphasis on their design, synthesis, and reactivity. These advances provide a versatile toolkit to advance the accessibility of SF5 incorporation in organic synthesis and medicinal chemistry.
Fields of Study & Subjects
Fluorine in Organic Chemistry
Synthesis and Catalytic Reactions
Click Chemistry and Applications
Publication details
- Journal / source
- Synthesis
- Publisher
- Georg Thieme Verlag KG
- Volume
- 58
- Issue
- 16
- Pages
- 1855–1862
- Publication date
- 14 April 2026
- Language
- EN