The Latest on Intrahepatic Cholestasis of Pregnancy – Update 2026
Abstract
Intrahepatic cholestasis of pregnancy (ICP) is the most common liver disorder specific to pregnancy. The condition is characterised by raised serum bile acids and aminotransferases and typically presents with pruritus as its defining symptom. Ursodeoxycholic acid remains the first line therapeutic option. Clinical management - including decisions regarding the timing of delivery - is guided principally by serum bile acid concentrations, with the aim of reducing perinatal complications. This review offers a clear and integrated overview of current diagnostic criteria, management strategies, and the evidence underpinning contemporary therapeutic recommendations.
Fields of Study & Subjects
Drug Transport and Resistance Mechanisms
Drug-Induced Hepatotoxicity and Protection
Liver Diseases and Immunity
Publication details
- Journal / source
- Geburtshilfe und Frauenheilkunde
- Publisher
- Georg Thieme Verlag KG
- Volume
- 86
- Issue
- 06
- Pages
- 528–537
- Publication date
- 1 June 2026
- Language
- DE