Titanium-Catalyzed Formal Dihydroacylation of Terminal Alkynes
Abstract
A titanium-catalyzed formal dihydroacylation of terminal alkynes is reported. The new process, in which the alkynes are directly converted into saturated aryl ketones, is based on an initial regioselective hydroaminoalkylation with a secondary benzylamine, a subsequent double-bond isomerization of the initially formed allylamine, and a final imine hydrolysis. The entire hydroaminoalkylation–hydrolysis sequence proceeds smoothly with variously substituted N-benzylanilines, but is limited to terminal alkynes without propargylic hydrogen atoms.
Fields of Study & Subjects
Catalytic C–H Functionalization Methods
Catalytic Alkyne Reactions
Asymmetric Hydrogenation and Catalysis
Publication details
- Journal / source
- Synthesis
- Publisher
- Georg Thieme Verlag KG
- Volume
- 58
- Issue
- 16
- Pages
- 1933–1940
- Publication date
- 7 April 2026
- Language
- EN