Methoxycarbonylation of Amines under Transition-metal and Solvent-free Condition with Dimethyl Carbonate
Abstract
Abstract In this work, KOtBu-promoted methoxycarbonylation reaction of amine using dimethyl carbonate as carbonyl source was presented under solvent-free condition. This reaction features mild reaction conditions (25–30 °C), short reaction time (0.5–3.0 h), broad substrate scope, and easy scale-up. Under standard reaction conditions, both N-aryl and N-alkyl substituted methyl carbamates (totally 37 examples) could be delivered in moderate to good yield (62–99%). Additional radical-trapping experiment using TEMPO as radical scavenger was conducted. Furthermore, representative carbamates were prepared in 10.0 g scale with no significant decrease of the yield.
Fields of Study & Subjects
Carbon dioxide utilization in catalysis
Catalytic C–H Functionalization Methods
Catalytic Cross-Coupling Reactions
Publication details
- Journal / source
- Synthesis
- Publisher
- Georg Thieme Verlag KG
- Volume
- 58
- Issue
- 17
- Pages
- 2036–2042
- Publication date
- 18 April 2026
- Language
- EN