Synthesis of N–N Linked Indolyl Quinazolinones via De Novo Construction of the Quinazolinone Ring
Abstract
Abstract A class of six-membered heterobiaryl indoles, N–N linked indolyl quinazolinones, has been accessed via the de novo construction of the quinazolinone ring. Addressing the scarcity of synthetic methods for N–N linked six-membered heterobiaryl indoles, a Brønsted acid-catalyzed (5 + 1) annulation/oxidation cascade of indole-derived 2-aminobenzamides and aldehydes was established. This protocol affords a structurally diverse library of N–N linked heterobiaryl indoles in excellent yields (up to 99%). This work enriches the extensive family of N–N linked heterobiaryl indoles with a new member possessing potential biological utility.
Fields of Study & Subjects
Quinazolinone synthesis and applications
Catalytic C–H Functionalization Methods
Multicomponent Synthesis of Heterocycles
Publication details
- Journal / source
- Synthesis
- Publisher
- Georg Thieme Verlag KG
- Volume
- 58
- Issue
- 14
- Pages
- 1615–1626
- Publication date
- 30 April 2026
- Language
- EN