Expanding the Chemical Space of DNA-encoded Libraries with Radical Reactivity
Abstract
Abstract DNA-encoded library (DEL) technology serves as a cornerstone of modern drug discovery, providing a cost-effective platform for the rapid interrogation of therapeutic candidates. However, the prerequisite for DNA-compatible synthetic reactions under aqueous conditions has historically constrained DEL chemical diversity to planar, C(sp2)-rich architectures, resulting from a reliance on traditional two-electron polar transformations. This short review evaluates recent advances in radical-mediated transformations as a powerful means to increase the chemical space of DELs. By facilitating access to three-dimensional sp3-rich scaffolds, these radical methodologies have the potential to significantly broaden the structural diversity of modern DELs.
Fields of Study & Subjects
Radical Photochemical Reactions
Chemical Synthesis and Analysis
Organoboron and organosilicon chemistry
Publication details
- Journal / source
- Synthesis
- Publisher
- Georg Thieme Verlag KG
- Volume
- 58
- Issue
- 20
- Pages
- 2342-2354
- Publication date
- 22 May 2026
- Language
- EN