Improved sleep quality and daytime function through a multi-herbal nutritional supplement containing Lactuca sativa and Melissa officinalis

Sleep disturbances are highly prevalent in modern societies and are often accompanied by impaired mood, cognitive dysfunction, and reduced quality of life [ 1 ] [ 2 ]. This exploratory, single-arm interventional study evaluated the effects of a novel nutritional supplement containing extracts of fresh Lactuca sativa L. herb, Melissa officinalis L., L-Tryptophan, and Magnesium on sleep quality and daytime performance in 50 healthy adults with self-reported sleep disturbances. Over a 14-day period, subjects consumed one sachet nightly. Sleep quality (primary endpoint) and secondary outcomes related to mood, cognition, and physiology were assessed using validated questionnaires, diaries, wearables, and polysomnography (N=10). Sleep quality scores (SF-B/R) improved by 14% overall (p=0.003), with a greater benefit in highly anxious individuals (+37%, p