Reconstruction and CSF Leak After Endoscopic Endonasal Approach of Clival Chordomas: A Systematic Review and Meta-Analysis

Journal of Neurological Surgery Part B Skull Base 2026

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Authors: Rudolfh Batista Arend, Pedro Henrique Ieggli, Bruno Zilli Peroni, Gabriel Lima Vieira Barbosa, Lucas Teles da Silva, Ana Clara Uliana Rezende, Amanda Delai Lobo, Natan Lucca Lima, Alex Roman, Martin Batista Coutinho da Silva, Pierre‐Olivier Champagne, Guilherme Gago
DOI: 10.1055/s-0046-1819063
Cited by: 0

Abstract

Objective: To determine pooled postoperative cerebrospinal fluid (CSF) leak rates after endoscopic endonasal approach (EEA) for clival chordomas and contextualize associated infectious and CSF-dynamic complications. Method: We systematically searched PubMed, Embase, Scopus, and Web of Science up to July 2025. We included studies reporting clival chordoma patients treated via an endoscopic endonasal approach with reconstructive details and postoperative CSF leak data; we excluded non-EEA approaches, non-chordoma histologies, non-English/Spanish/Portuguese, series with

Fields of Study & Subjects

Head and Neck Surgical Oncology Bone Tumor Diagnosis and Treatments Neurosurgical Procedures and Complications

Publication details

Journal / source
Journal of Neurological Surgery Part B Skull Base
Volume
87
Issue
S 01
Pages
S1–S548
Publication date
27 February 2026
Language
EN