Diagnostic Accuracy of Quantitative Diffusion and Perfusion MRI Parameters in Preoperative Staging of Endometrial Cancer

Abstract To determine the diagnostic accuracy of quantitative diffusion and MR perfusion parameters in characterizing, staging, and grading endometrial carcinoma (EC). Diffusion and MR perfusion were performed on 45 biopsy-proven patients with EC. The deep myometrial invasion (DMI), cervical stromal invasion (CSI), and lymph node metastasis (LNM) were assessed on T2WI. The quantitative diffusion (apparent diffusion coefficient [ADC]) and perfusion parameters (Ktrans, Kep, Ve, Vp, SImax, SIrel, and TTP) were derived. The diagnostic accuracy of these parameters in the characterization, staging and grading of EC was determined along with their validation with histological type, grading, and stage. Their relationship with the type of inflammatory infiltrate and microvessel density (MVD) using CD34 on histopathology was also studied. The ADC and perfusion parameters, Ktrans and Ve, showed significant results (p-value