Reduced Claudin-3 Expression Is Linked to Unfavorable Tumor Features and Poor Prognosis in Non-Small Cell Lung Cancer

Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie 2026 Open access

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Authors: Nina Schraps, Martin Reck, Birgit Hantzsch-Kuhn, Till Olchers, David Benjamin Ellebrecht, K. Möller, Christoph Fraune, Maximilian Lennartz, Florian Lutz, M Kluth, Georgia Makrypidi‐Fraune, Ronald Simon
+3 more G Sauter, S Steurer, Sönke von Weihe
DOI: 10.1055/s-0046-1824832
Cited by: 0
References: 47

Abstract

Background: Claudin 3 (CLDN3) is a transmembrane protein which forms tight junctions (TJs) together with other claudins, occludin, and junctional adhesion molecules. Because of its membranous localization CLDN3 is a potential therapeutic target. Altered CLDN3 has been proposed as a prognostic feature in lung cancer and other tumors. Material and Methods: To better understand the prevalence of expression and its impact on the prognosis of different lung cancer subtypes, we investigated CLDN3 expression by immunohistochemistry in a set of tissue microarrays containing 858 resected lung cancers. Results: CLDN3 positivity was markedly more frequent and more intense in pulmonary adenocarcinoma (AC, 95.9% positive) than in squamous cell carcinoma (SCC, 53.3%; p

Fields of Study & Subjects

Barrier Structure and Function Studies Caveolin-1 and cellular processes Calcium signaling and nucleotide metabolism

Publication details

Journal / source
Zentralblatt für Chirurgie - Zeitschrift für Allgemeine Viszeral- Thorax- und Gefäßchirurgie
Volume
151
Issue
S 01
Pages
1–10
Publication date
1 January 2026
Language
DE