Sequencing of Pleural Fluid and Plasma for Tuberculous Pleuritis

NEJM Evidence 2026

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Authors: WK Jacky Lam, Ken K. P. Chan, Guangya Wang, Christopher K.C. Lai, Guannan Kang, Christopher Chan, Angela C. Y. Leung, Natalie H. L. Wong, Crystal S. N. Tso, KM Chow, Saravanan Ramakrishnan, K. T. Wong
+24 more Charlotte H. Y. Lau, Joyce Ng, Rachel L. P. Lo, W.-H. Yip, Jenny C. L. Ngai, K. W. To, Irene O L Tse, S.H. Cheng, Huimin Shang, C W, A Lai, Charles M. L. Chan, Vicky C.T. Lee, Yasine Malki, L CHOY, L Mary-Jane, Qing Zhou, Stephanie C. Y. Yu, Peiyong Jiang, Fanny W.S. Ko, K. C. Allen Chan, David S.C. Hui, Y. C. Gary Lee, Y. M. Dennis Lo
DOI: 10.1056/evidoa2500237
Cited by: 2
References: 26

Abstract

BACKGROUND: in the pleural space, resulting in low sensitivity of microbiological culture and polymerase chain reaction-based analyses on pleural fluid. The use of metagenomic next-generation sequencing for diagnosing TBP may be limited by the background noise of DNA from nontuberculous mycobacteria. METHODS: sequencing as described above and culture using McNemar's test. RESULTS: culture (P

Fields of Study & Subjects

Pleural and Pulmonary Diseases Pericarditis and Cardiac Tamponade Tuberculosis Research and Epidemiology

Publication details

Journal / source
NEJM Evidence
Publisher
Massachusetts Medical Society
Volume
5
Issue
4
Pages
EVIDoa2500237–EVIDoa2500237
Publication date
24 March 2026
Language
EN