A 12,000-Year-Old Case of NPR2 -Related Acromesomelic Dysplasia

New England Journal of Medicine 2026 Open access

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Authors: Daniel M. Fernandes, Alejandro Llanos-Lizcano, Florian Brück, Victoria Oberreiter, Kadir Toykan Özdoğan, Olivia Cheronet, Michaela Lucci, Albert M. Beckers, Patrick Pétrossians, Alfredo Coppa, Ron Pinhasi, Adrian Daly
DOI: 10.1056/nejmc2513616
Cited by: 0
References: 5

Abstract

Rare disease in an adolescent who lived more than 12,000 years ago, along with her burial embrace by a first-degree relative, may reflect the importance of care for survival. Ancient DNA analysis led to a genetic diagnosis.

Fields of Study & Subjects

Paleopathology and ancient diseases Genomics and Rare Diseases Connective tissue disorders research

Publication details

Journal / source
New England Journal of Medicine
Volume
394
Issue
5
Pages
513–515
Publication date
28 January 2026
Language
EN