Potassium Levels and Risk of Ventricular Arrhythmias
Abstract
To the Editor: In the POTCAST (Targeted Potassium Levels to Decrease Arrhythmia Burden in High-Risk Patients with Cardiovascular Diseases) trial, Jøns et al. (Nov. 20 issue) 1 found compelling evidence that keeping potassium levels in the high-normal range may mitigate the risk of ventricular arrhythmias among persons with an implantable cardioverter–defibrillator (ICD). Although this finding is commendable, the interpretation of safety warrants further precision from a renal viewpoint. Although persons with an estimated glomerular filtration rate (eGFR) of less than 30 ml per minute per 1.73 m 2 of body-surface area were excluded from the trial, the distribution of participants across chronic . . .
Fields of Study & Subjects
Potassium and Related Disorders
Cardiac electrophysiology and arrhythmias
Cardiac pacing and defibrillation studies
Publication details
- Journal / source
- New England Journal of Medicine
- Volume
- 394
- Issue
- 7
- Pages
- 723–726
- Publication date
- 11 February 2026
- Language
- EN