Barrett’s Esophagus
Abstract
Barrett's esophagus develops as a result of chronic acid and bile reflux and carries an increased risk of esophageal adenocarcinoma. Because it has no specific symptoms, many patients do not receive a diagnosis or they present with symptoms of gastroesophageal reflux disease and other related risk factors or complications. Diagnosis relies on endoscopic and histopathological findings, including a visible columnar-cell-lined segment measuring at least 1 cm long that contains intestinal metaplasia with goblet cells. Ongoing surveillance focuses on early detection of malignant progression, particularly high-grade dysplasia and early-stage cancer, which allows curative endoscopic treatment and avoids the adverse effects associated with chemotherapy or esophagectomy. Participation in clinical trials is encouraged to improve detection, risk stratification, and management strategies.
Fields of Study & Subjects
Esophageal Cancer Research and Treatment
Eosinophilic Esophagitis
Esophageal and GI Pathology
Publication details
- Journal / source
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Volume
- 394
- Issue
- 17
- Pages
- 1723–1735
- Publication date
- 29 April 2026
- Language
- EN