Balanced Fluid or 0.9% Saline in Children Treated for Septic Shock

New England Journal of Medicine 2026 Open access

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Authors: Fran Balamuth, Scott L. Weiss, Elliot Long, Graham C. Thompson, Amanda Artis, Atzael B. Campos, Meredith L Borland, Stuart R. Dalziel, Adriana Yock‐Corrales, Ruchi Singh, Amanda Williams, Beata Mickiewicz
+50 more Christopher Hickey, Julie C. Fitzgerald, Benjamin L. Laskin, Robert W. Hickey, Michelle Eckerle, Waleed Alqurashi, Elizabeth R. Alpern, Lilliam Ambroggio, Mohamed Badawy, Shannon Baumer-Mouradian, Simon Berthelot, Lindsay D. Clukies, Simon Craig, Sarah Curtis, Adrienne L. Davis, Susan Duffy, Matthew A. Eisenberg, Jason G. Emsley, Ara Festekjian, Shane George, Rebecca Green, Karen E Gripp, Priya G. Jain, Shefali Jani, Gary Joubert, Pavan Judge, April Kam, Amit Kochar, Ioannis Koutroulis, Maria Y. Kwok, Roni D. Lane, Anna Lithgow, J. Lloyd, Karim Mansour, Julie K. McManemy, Claudia Morris, NJ Phillips, Arjun Rao, Alexander Rogers, Anupam Sehgal, Yasaman Shayan, Jonathan Silverman, Eunicia Tan, Neil G. Uspal, Cheryl Vance, Emma Whyte, Jing Huang, Stephen B. Freedman, Franz E. Babl, Nathan Kuppermann
DOI: 10.1056/nejmoa2601969
Cited by: 8
References: 32

Abstract

BACKGROUND: Whether treatment with balanced crystalloid fluid leads to better outcomes than 0.9% saline in children treated for septic shock is debated. METHODS: In this pragmatic clinical trial conducted at 47 emergency departments in five countries, patients (2 months to

Fields of Study & Subjects

Trauma Hemostasis Coagulopathy Resuscitation Acute Kidney Injury Research Sepsis Diagnosis and Treatment

Publication details

Journal / source
New England Journal of Medicine
Publisher
Massachusetts Medical Society
Volume
395
Issue
9
Pages
870–881
Publication date
24 April 2026
Language
EN