Sex Hormone Influences on Venous Thrombotic and Cardiovascular Risk
Abstract
Thrombosis is a recognized complication of sex hormone therapy, which includes hormone replacement for deficiencies, contraceptive therapy, treatment of heavy menstrual bleeding, gender-affirming hormone therapy, suppression of ovulation, oncologic hormone therapy, and assisted reproduction. This review examines the effects of sex hormones on hemostasis and the vasculature and summarizes current evidence on thrombotic risk, including the effects of hormone formulation, thrombophilias, previous thrombosis, and common clinical factors. Practical guidance on the prevention and treatment of hormone-associated venous thromboembolism, as well as on perioperative care of patients receiving sex hormone therapy, is also provided.
Fields of Study & Subjects
Blood Coagulation and Thrombosis Mechanisms
Menopause: Health Impacts and Treatments
Coagulation
Bradykinin
Polyphosphates
and Angioedema
Publication details
- Journal / source
- New England Journal of Medicine
- Publisher
- Massachusetts Medical Society
- Volume
- 394
- Issue
- 15
- Pages
- 1514–1528
- Publication date
- 15 April 2026
- Language
- EN