Electrospun polycaprolactone/ polyethylene oxide blends with optimal conditions for scaffold application

This study investigates the fabrication and characterization of electrospun scaffolds made from varying proportions of polycaprolactone (PCL) and polyethylene oxide (PEO). The study explains how electrospinning parameters (polymer concentration and voltage) affect the chemical and physical features of PCL/PEO blends. The optimum conditions and concentrations for these blends are found to be suitable for medical applications as scaffolds or drug delivery systems. The mixture of PCL and PEO was dissolved in chloroform to create homogeneous solutions. The electrospinning technique was used to fabricate fibrous mats, which were analyzed for their physical and chemical characteristics. The wettability of the fibrous mat surfaces was assessed using the contact angle. The study found that increasing PEO concentration to 3% in the blend specimen electrospun at 25 KV voltage enhanced membrane wettability and produced more homogeneous fibrous structures, facilitating the creation of biocompatible materials for soft tissue regeneration. The Fourier Transform Infrared Spectroscopy (FTIR) results showed that the strength of the PCL characteristic peaks got weaker as the PEO concentrations increased.