Synthesis, identification, and antibacterial effect assessment of new thiazolidinones from some imines bearing substituted phenyl sulphonyl amides

A series of new thiazolidinone derivatives (N22-N42) has been prepared from the reaction of some Schiff bases (N1-N21) containing sulfonylamide group with thioglycholic acid in dry benzene. The whole synthesized chemical materials have been identified through FT – IR spectroscopy. Structures for some of the newly synthesized chemical materials have been proved by proton magnetic rsonance (1H-NMR) using (DMSO-d6) as a solvent and mass spectroscopy. The biological activity effect of these chemical products has been studied against certain types of bacteria: gram – positive (Streptococcus pneumonia) and gram – negative (Pseudomonas aerugenosa). Additionally, the anti fungal effect of some chemical products was investigated toward Aspergillus species and the resulte were correlated with fungal Nystatin as control sample. The results were indicated the highest inhibtion zone diameter value for derivatives (N36, N34 and N42). These chemical compounds revealed a promising bioactivity against these microbial agents.