Formulation and in vitro evaluation of sitaformin invasomal gel

The Polycystic ovarian syndrome (PCOS), most common prevention of endocrine disorder which is typified by hyperandrogenism, ovulatory failure, and polycystic ovaries. Inadequate efficacy and systemic side effects frequently restrict the available treatment alternatives. A promising method for effective and targeted medication delivery is the use of nanotechnology, especially in innovative delivery systems as invasomal gels. In order to treat PCOS locally, this study intends to create and assess an invasomal gel that improves drug penetration and reduces systemic side effects. Phospholipids, ethanol, and edge activators were used to create invasomal gels, which formed flexible vesicles capable of penetrating deeply into the skin. Optimizing the vesicle shape for improved drug encapsulation and controlled release was made possible in large part by nanotechnology. The physicochemical characteristics of the formulations were described, and the penetration potential in comparison to conventional formulations was evaluated using Franz diffusion cells. Studies on in vitro skin penetration showed that the invasomal gel, which had ideal physicochemical properties, greatly improved drug delivery. This implies that the invasomal gel based on nanotechnology may provide better therapeutic results for the treatment of PCOS. Nevertheless, additional in vivo research is required to confirm its therapeutic effectiveness and safety.