Factors associated with nonalcoholic fatty liver disease in individuals with type 2 diabetes

Type 2 diabetes mellitus (T2DM) and Non-alcoholic fatty liver disease (NAFLD) often coexist and synergistically drive detrimental effects. This study aimed to determine factors associated with non-alcoholic fatty liver disease associated with type 2 diabetes mellitus and explore the factors contributing to liver fibrosis. Seventy Type 2 diabetes mellitus patients aged 35–77 years were included in this study. Blood analyses were conducted at the Laboratory of Al-Hindiya / Kerbala, measuring levels of glucose, insulin, homeostasis model assessment, liver enzymes, lipid profiles, uric acid, and vitamin D. Serum asprosin and adiponectin concentrations were also measured using ELISA, following the manufacturer’s instructions. The results indicated that patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease exhibited elevated levels of lipid profiles, liver enzymes, uric acid, and increased serum concentrations of asprosin and adiponectin compared to the control group. In patients with T2DM and NAFLD, asprosin and adiponectin were identified as key contributing factors for Liver fibrosis.