Evaluation of paraoxonase, ceruloplasmin and some biochemical parameters in Iraqi patients with migraine

The molecular mechanisms underlying migraine, a complex neurological disease, are yet unknown. The pathogenesis regarding migraine is thought to be influenced by oxidative stress. The aim of the presented work is assessing ceruloplasmin (CP), serum paraoxonase (PON), fasting blood sugare (FBS), glutathione (GSH), insulin, triglyceride glucose index (TyG), homeostasis model assessment for insulin resistance (HOMA-IR), total protein (TP), lipid profile, globulin, albumin, uric acid, creatinine, and paraoxonase as well as their correlation with other parameters in patients experiecing migraine. Fifty matched healthy controls—21 men and 29 women—and fifty patients—nine males and forty-one females—have been enrolled. The current work’s findings showed that the migraine patients’ (MP) serum levels of GSH, paraoxonase, albumin, TP, and creatinine were considerably lower (P less than 0.01) than those of the healthy control group (HC). There were increase significance P