Regression of massive left ventricular hypertrophy in Danon disease
Abstract
Danon disease is a rare X-linked multi-system lysosomal storage disorder. It may manifest as severe cardiomyopathy in affected individuals, with different clinical courses observed for men and women. Women may experience a hypertrophic or a dilated/hypokinetic phenotype irrespective of their disease stage. Men typically present earlier with progressive hypertrophy, and rapid regression of their hypertrophy with dilation and hypokinesis with onset of heart failure outcomes. In this case we demonstrate echocardiographic images of a young male taken just 2 years apart.
Fields of Study & Subjects
Cardiomyopathy and Myosin Studies
Cardiovascular Effects of Exercise
Cellular transport and secretion
Publication details
- Journal / source
- Acta cardiologica. Supplementum
- Publisher
- Informa UK Limited
- Volume
- 81
- Issue
- 2
- Pages
- 245–246
- Publication date
- 7 February 2026
- Language
- EN