Differences in clinical presentation between heart failure patients with reduced and preserved ejection fraction – analysis of the INTELHEART database

Acta cardiologica. Supplementum 2026

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Authors: M Belopavlovic, Milan Rodić, Nikola Stipic, Andrej Preveden, Aleksandra Milovančev, Svetlana Apostolovic, Tamara Filipović, Stefan M. Simovic, Goran Davidović, Marija Polovina, Smiljana Tomašević, Tijana Geroski
+3 more Nenad Filipović, D J Jakovljevic, L V Velicki
DOI: 10.1080/00015385.2026.2677977
Cited by: 1
References: 32

Abstract

BACKGROUND: Heart failure (HF) is a major global health issue with significant morbidity, mortality, and economic burden. Differentiating between heart failure with reduced ejection fraction (HFrEF) and preserved ejection fraction (HFpEF) is essential for diagnosis, prognosis, and treatment. The aim of this study was to evaluate and compare the clinical, laboratory, and echocardiographic characteristics of patients with HFrEF and HFpEF. METHODS: This retrospective, multicentre study included 2156 patients diagnosed with HF between 2003 and 2023 across four Serbian medical institutions. Patients were classified into HFrEF (LVEF

Fields of Study & Subjects

Heart Failure Treatment and Management Cardiovascular Function and Risk Factors Cardiac pacing and defibrillation studies

Publication details

Journal / source
Acta cardiologica. Supplementum
Publisher
Informa UK Limited
Volume
81
Issue
4
Pages
579–588
Publication date
21 April 2026
Language
EN