Further computations on the solubility of theophylline in water + alcohol mixtures at various temperatures

The experimental solubility data of theophylline in three hydro-alcoholic solvent mixtures at various temperatures were re-analysed concerning practical needs in the pharmaceutical industry. The minimum number of known solubility data in the binary solvents was used as a training data set and the rest of data were predicted using the trained models. In addition, the data was predicted using a previously trained model employing Abraham parameters and the experimental solubility of the drug in the mono-solvents as input values. The accuracy of the provided prediction tools was satisfactory. The results were also compared with those of the models reported in an earlier paper. Moreover, by means of the Gibbs and van’t Hoff equations apparent thermodynamic functions of dissolution were calculated observing positive quantities in all cases indicating endothermic and entropy-driven processes.