Abraham solvation parameter model: experiment-based solute descriptor values for potential medicinal candidates, dietary healthcare supplements and pharmaceutical formulation ingredients
Abstract
Experiment-based Abraham model solute descriptors have been determined for oxibendazole, 3,3’-diindolylmethane, meglumine, N-acetyl-L-phenylalanine and tranilast based on recently published mole fraction solubility data. The calculated descriptor values, when inserted into the respective Abraham model correlation, provided a reasonably accurate mathematical description of the observed solubility behaviour, with deviations between the measured and back-calculated values being on the order of ±0.17 log units (or less).
Fields of Study & Subjects
Complementary and Alternative Medicine Studies
Computational Drug Discovery Methods
Drug Solubulity and Delivery Systems
Publication details
- Journal / source
- Physics and Chemistry of Liquids
- Publisher
- Informa UK Limited
- Volume
- 64
- Issue
- 5
- Pages
- 834–850
- Publication date
- 1 July 2026
- Language
- EN