Assessment of pancreatic exocrine insufficiency and pancreatic enzyme dose-response using the 13 C-Mixed triglyceride breath test

Scandinavian Journal of Gastroenterology 2026 Open access

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Authors: Mathias Ellgaard Cook, Dean Campbell, Marianne Køhler, Tina Okdahl, J. Enrique Domínguez‐Muñoz, J.-Matthias Löhr, Miroslav Vujasinović, Jutta Keller, Péter Hegyi, Søren Schou Olesen, Asbjørn Mohr Drewes
DOI: 10.1080/00365521.2026.2623134
Cited by: 0
References: 20

Abstract

Introduction Faecal elastase-1 testing is the most commonly used method for diagnosing pancreatic exocrine insufficiency (PEI), but has poor diagnostic precision and cannot guide titration of pancreatic enzyme replacement therapy (PERT). An alternative is 13C-mixed triglyceride breath test. We investigated concordance between breath test and faecal elastase-1, and response to bicarbonate-buffered enzymes.Methods In this prospective study, adults with faecal elastase

Fields of Study & Subjects

Pancreatitis Pathology and Treatment Clinical Nutrition and Gastroenterology Pancreatic and Hepatic Oncology Research

Publication details

Journal / source
Scandinavian Journal of Gastroenterology
Volume
61
Issue
4
Pages
459–467
Publication date
2 February 2026
Language
EN