6-Amino-7-fluoro-2 H -benzo[ b ][1,4]oxazin-3(4 H )-one, a crucial intermediate in the synthesis of herbicides, flumioxazin and thidiazimin

Synthetic Communications 2026

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Authors: Prakash Suman Behera, Devendra Nagineni, Naga Pranathi Abburi, Srinivas Kantevari
DOI: 10.1080/00397911.2025.2612513
Cited by: 0
References: 7

Abstract

An efficient synthesis of 6-amino-7-fluoro-2H-benzo[b][1,4]oxazin-3(4H)-one, a key intermediate in the preparation of the herbicides flumioxazin and thidiazimin, is accomplished in three steps from readily available 1,3-difluorobenzene. The key steps of nitration, condensation, and reductive cyclization were optimized to obtain the product in 78% overall yield with 99.4% purity.

Fields of Study & Subjects

Quinazolinone synthesis and applications Structural and Chemical Analysis of Organic and Inorganic Compounds Synthesis and Biological Evaluation

Publication details

Journal / source
Synthetic Communications
Volume
56
Issue
1
Pages
44–52
Publication date
2 January 2026
Language
EN