DCC-mediated [3 + 2] annulation between arylisothiocyanate and thioglycolic acid to access N -phenyl rhodanines
Abstract
A highly efficient and straightforward [3 + 2] annulation reaction between arylisothiocyanate and thioglycolic acid to facilitated a diverse array of N-phenyl rhodanines by using N,N’-dicyclohexylcarbodiimide (DCC) has been explored. The primarily role of DCC is to activate thioglycolic acid which simplify [3 + 2] annulation reaction. Notably, the advantages of the present methodology included availability of starting material, ease of operation, mild reaction condition, and acceptable yield.
Fields of Study & Subjects
Synthesis and Reactivity of Sulfur-Containing Compounds
Sulfur-Based Synthesis Techniques
Synthesis of heterocyclic compounds
Publication details
- Journal / source
- Synthetic Communications
- Volume
- 56
- Issue
- 3
- Pages
- 226–234
- Publication date
- 28 January 2026
- Language
- EN