Serum biomarkers sE-selectin and CCL5: indicators of postoperative delayed cerebral edema in hypertensive intracerebral hemorrhage

OBJECTIVE: This investigation assessed the predictive value of serum soluble E-selectin (sE-selectin) and C motif chemokine ligand 5 (CCL5) for delayed cerebral edema (DCE) following hematoma removal in patients with hypertensive intracerebral hemorrhage (HICH). METHODS: The study retrospectively included 260 patients with HICH who underwent neuroendoscopic hematoma removal at The Central Hospital of Yongzhou (Yongzhou Hospital Affiliated to University of South China), categorizing them into DCE and Non-DCE groups. General baseline data were collected and preoperative serum sE-selectin and CCL5 levels were measured. The correlation between serum sE-selectin and CCL5 levels was analyzed and the risk factors for DCE after neuroendoscopic hematoma removal in patients with HICH were identified. Receiver operating characteristic (ROC) curves were plotted to analyze the predictive value of serum sE-selectin and CCL5 alone and in combination for DCE. RESULTS: Serum sE-selectin and CCL5 levels were higher in the DCE group than in the Non-DCE group. There was a moderate positive correlation between serum sE-selectin and CCL5 levels in patients with HICH. Elevated serum sE-selectin and CCL5 levels were independent risk factors for DCE after neuroendoscopic hematoma removal in patients with HICH. The predictive efficacy for DCE after neuroendoscopic hematoma removal in HICH patients was higher when serum sE-selectin and CCL5 were used in combination. Higher sE-selectin or CCL5 increased the incidence of DCE after neuroendoscopic hematoma removal in patients with HICH. CONCLUSION: In patients with HICH who experienced DCE following neuroendoscopic hematoma removal, serum sE-selectin and CCL5 are higher, and both markers could help predict DCE.