Analyses of the 2025 Nobel Prize in Physiology or Medicine: Treg Cell-Mediated Peripheral Immune Tolerance
Abstract
Drs. Mary E. Brunkow, Frederick J. Ramsdell, and Shimon Sakaguchi were awarded the 2025 Nobel Prize in Physiology or Medicine for their foundational contributions to the identification of CD4+CD25+FOXP3+ regulatory T cells (Tregs), which pioneered the field of Treg cell-mediated peripheral immune tolerance. Their work elucidated the mechanisms by which immune cells are suppressed to prevent autoimmunity and provided critical insights that support the advancement of Treg-based immunotherapeutic strategies for autoimmune diseases. Following an overview of immune tolerance, autoimmunity, and Treg cell-mediated peripheral immune tolerance is a bibliometric analysis of each of this year’s Nobel laureates and their respective scholarly contributions.
Fields of Study & Subjects
T-cell and B-cell Immunology
Psoriasis: Treatment and Pathogenesis
Reproductive System and Pregnancy
Publication details
- Journal / source
- Science & Technology Libraries
- Volume
- 45
- Issue
- 3
- Pages
- 225–240
- Publication date
- 27 February 2026
- Language
- EN