Systemic coagulation and fibrinolytic alterations in eosinophilic asthma with and without nasal polyps

Objective Asthma with nasal polyps constitutes a distinct eosinophilic phenotype marked by inflammation and altered coagulation. This study aimed to compare systemic coagulation and fibrinolytic profiles in eosinophilic asthma with and without nasal polyps.Methods Seventy-two participants were enrolled: eosinophilic asthma with nasal polyps (n = 28), eosinophilic asthma without nasal polyps (n = 22), and age-, sex-, and body mass index–matched healthy controls (n = 22). To minimize confounding, participants were devoid of chronic comorbidities or medications affecting coagulation. Asthma patients were stable on maintenance corticosteroids. Blood eosinophil counts and hemostatic biomarkers [tissue plasminogen activator (tPA), plasminogen activator inhibitor 1 (PAI-1), α2-antiplasmin, D-dimer, fibrinogen, activated partial thromboplastin time (aPTT), international normalized ratio (INR), Factors V and VIII, and thrombin-antithrombin III complex (TAT)] were measured.Results Compared with controls, non-polyp asthma showed higher tPA and fibrinogen levels, whereas the nasal polyp subgroup exhibited shorter aPTT and higher PAI-1. TAT levels were significantly lower in the nasal polyp subgroup than in the non-polyp subgroup (p < 0.05). In the overall asthma group, eosinophils correlated negatively with Factor V and PAI-1. Distinctly, the nasal polyp subgroup showed the lowest aPTT and Factor VIII levels, with eosinophils positively correlating with Factor VIII (r = 0.638, p < 0.001).Conclusion Eosinophilic asthma with nasal polyps is characterized by distinct hemostatic alterations, including shorter aPTT, higher PAI-1, and lower TAT levels compared to the non-polyp phenotype. These findings suggest a specific link between type 2 inflammation and systemic hemostasis regulation in this subgroup.