Prognostic Significance of Different Ki-67 Cutoff Values Defined Luminal B HER2-Negative Breast Cancer
Abstract
Luminal B (HER2-) breast cancer is defined as ER- or PR-positive and HER2-negative meeting with PR ≤ 20%, or ER- or PR-positive and HER2-negative with high Ki-67 index, which has worse prognoses. The locally specified Ki-67 cutoff value has remained elusive in China. 4940 patients with ER- or PR-positive and HER2-negative operable breast cancer were recruited. The novel findings was that luminal B (HER2-) tumors showed poor DFS regardless of Ki-67 cutoff values (14, 20 or 30%), and luminal B (HER2-) subtype(PR ≤ 20% and high Ki-67 index) tumors showed inferior OS, DMFS, and BCSS. With Ki-67 cutoff value of 20%, it was optimized to distinguish prognostic differences.
Fields of Study & Subjects
Breast Cancer Treatment Studies
Breast Lesions and Carcinomas
HER2/EGFR in Cancer Research
Publication details
- Journal / source
- Cancer Investigation
- Volume
- 44
- Issue
- 5
- Pages
- 463–478
- Publication date
- 2 February 2026
- Language
- EN