Association between urine triclocarban concentration and the prevalence of hypertension based on a cross-sectional study

Background There is a correlation between triclocarban exposure and adverse health effects, but the association between triclocarban and hypertension remains unknown. This study is to investigate the relationship between urinary triclocarban and the risk of hypertension in adults.Methods Participants were enrolled from the National Health and Nutrition Examination Surveys. The urinary concentrations of triclocarban were measured by derivatization gas chromatography-mass spectrometry. Odds ratio (OR) and 95% confidence interval (CI) of urinary triclocarban associating with hypertension were estimated with by multivariable logistic regressions. Non-linear correlations were explored using restricted cubic splines. Subgroup analysis was carried out to examine the interactive effects.Results The highest tertiles of triclocarban comparing the lowest tertiles was associated with higher risk of hypertension in unadjusted model (OR 1.93, 95%CI 1.53 to 2.44; P < 0.001), partly-adjusted model (OR 1.48, 95%CI 1.11 to 1.97; P = 0.008) and fully-adjusted model (OR 1.31, 95%CI 1.02 to 1.80; P = 0.043). Subgroup analysis showed that the relationship was consistent across gender, age, race and BMI groups.Conclusions Urinary triclocarban was associated with the prevalence of hypertension, after adjusting for traditional risk factors.