Celery leaf extract attenuates inflammation in a murine model of carrageenan-induced paw edema via modulation of NF-κB and antioxidant pathways

The current investigation examined carrageenan model-induced paw inflammation in mice, as well as the potential protective effects of celery leaf extract. Apparently, signs of inflammatory reactions triggered by carrageenan infusion include elevated levels of inflammatory and antioxidant markers, including C-reactive protein levels. Transcription of tumour necrosis factor-alpha, interleukin-1beta, interleukin-2, nitric oxide, cyclooxygenase-2, prostaglandin E2, monocyte chemoattractant protein-1, and myeloperoxidase activity, as well as decreases in other factors, such as interleukin-10 and glutathione content were also observed. Remarkably, it became apparent that extracts derived from celery leaves could prevent the formation of oxidative damage, suppress inflammatory signaling, and alleviate histological alterations in painful, inflamed, reddish paw tissue upon being infused with carrageenan. Our documented scientific findings provide promising evidence that the herbal extract of celery leaves may be employed as a complementary approach for ameliorating the pathophysiological and histological alterations associated with the onset of paw edema.