Effects of extended-release topical polyhexanide in a Staphylococcus aureus–induced murine dermatitis model characterized by IL-36 expression
Abstract
OBJECTIVES: -induced cutaneous inflammation characterized by IL-36 expression. METHODS: exposure protocol, with confirmation of IL-36 protein expression. Animals were treated topically with GX03 or left untreated. Disease severity was assessed with blinded investigator global assessment scoring using the validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD). RESULTS: = 0.0003). CONCLUSIONS: These findings suggest that extended-release topical polyhexanide (GX03) reduces disease severity in a murine dermatitis model characterized by IL-36 expression.
Fields of Study & Subjects
Dermatology and Skin Diseases
Psoriasis: Treatment and Pathogenesis
Advancements in Transdermal Drug Delivery
Publication details
- Journal / source
- Journal of Dermatological Treatment
- Publisher
- Informa UK Limited
- Volume
- 37
- Issue
- 1
- Pages
- 2667686–2667686
- Publication date
- 26 May 2026
- Language
- EN