Dosimetric correlation of integral dose-dependent lymphopenia in bone marrow after pelvic radiotherapy in locally advanced prostate cancer
Abstract
PURPOSE: We investigated dosimetrically lymphopenia concerning radiotherapy (RT) in patients receiving pelvic RT due to locally advanced prostate cancer (LAPCA). MATERIALS AND METHODS: A total of 195 patients with lymph node-positive LAPCA were retrospectively evaluated and included in this single-center study. The relationship among absolute lymphocyte count (ALC), treatment modality, clinical stage, RT dose, and existence of pre-RT and post-RT lymphopenia (Grade≥2) was evaluated. Dependent McNemar analyses revealed significant relationship in pre-RT and post-RT (p
Fields of Study & Subjects
Inflammatory Biomarkers in Disease Prognosis
Prostate Cancer Diagnosis and Treatment
Effects of Radiation Exposure
Publication details
- Journal / source
- International Journal of Radiation Biology
- Publisher
- Informa UK Limited
- Volume
- 102
- Issue
- 5
- Pages
- 493–502
- Publication date
- 17 February 2026
- Language
- EN