Integrating experimental data and modeling to unravel cell damage responses in monoenergetic neutron fields

International Journal of Radiation Biology 2026 Open access

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Authors: Géraldine Gonon, Yann Thibaut, Juan S. Martinez, Richard Babut, Aurélie Vaurijoux, Petit Michaël, Y. Perrot, C. Villagrasa, Gaëtan Gruel
DOI: 10.1080/09553002.2026.2637706
Cited by: 0
References: 49

Abstract

Purpose Human exposure to mixed ionizing radiation fields presents challenges in understanding subcellular effects due to heterogeneous energy deposition. This study investigates DNA damage in primary endothelial cells exposed to monoenergetic neutrons (2.5 or 15.1 MeV), which generate complex secondary charged particle fields.Materials and methods Cells were irradiated on a human torso water phantom at 0.13 or 2.11 cm mean depth, 3.20 cm from the neutron source. Three independent experiments were performed per setup at low absorbed doses (

Fields of Study & Subjects

Radiation Therapy and Dosimetry Effects of Radiation Exposure DNA Repair Mechanisms

Publication details

Journal / source
International Journal of Radiation Biology
Volume
102
Issue
6
Pages
588–604
Publication date
13 March 2026
Language
EN