Establishment of a mechano-biological computational framework for fracture healing and investigation of initial condition effects
Abstract
This study developed a computational framework for mechano-biological regulation of fracture healing, integrating four finite element modules: mechanical stimulus calculation, vascular reconstruction prediction, cell migration and differentiation, and tissue modulus updating. Based on this framework, the effects of initial geometric conditions, initial modulus of granulation tissue, mesenchymal stem cell (MSC) diffusion coefficient, vascular reconstruction parameters, and loading conditions on the speed and quality of healing were systematically analyzed. The results demonstrate that initial conditions play a significant regulatory role in the rate and quality of fracture healing.
Fields of Study & Subjects
Bone fractures and treatments
Elasticity and Material Modeling
Heterotopic Ossification and Related Conditions
Publication details
- Journal / source
- Computer Methods in Biomechanics & Biomedical Engineering
- Publisher
- Informa UK Limited
- Pages
- 1–16
- Publication date
- 3 February 2026
- Language
- EN