Research on the effects and mechanisms of the Yiqi Huoxue Recipe in improving renal injury in diabetic nephropathy through the HIF-1 pathway

Journal of Asian Natural Products Research 2026 Open access

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Authors: Wen-Di Niu, Hao-Wei Liang, Lue Hong, JinXing He, Jiahui Qian, Fei Pan, Zhi-Wei Xu, Hui Wang
DOI: 10.1080/10286020.2025.2602695
Cited by: 0
References: 28

Abstract

This study investigates the therapeutic effects and mechanisms of the Yiqi Huoxue Recipe (YHR) on renal injury in Diabetic nephropathy (DN). Through mass spectrometry analysis, animal experiments, and network pharmacology approaches, it was found that YHR can ameliorate renal function indicators and pathological changes in DN rats, and reduce cell apoptosis. Mechanistic studies indicate that YHR alleviates hyperglycemia-induced renal inflammation and damage by inhibiting the HIF-1 signaling pathway, thereby improving DN.

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Traditional Chinese Medicine Analysis Medical Research and Treatments

Publication details

Journal / source
Journal of Asian Natural Products Research
Volume
28
Issue
9
Pages
1412–1436
Publication date
12 January 2026
Language
EN