Discovery of undescribed alkaloids with immunosuppressive activity from the endophytic fungus Penicillium sp. HZ-5

Journal of Asian Natural Products Research 2026

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Authors: Jie Li, Ye-Ting Zhang, Ye-Ting Zhang, Yusuf Abudula, Zhangrong Hou, Zheng-Yi Shi, Xin-Ye Huang, Ming Chen, Xue-Qi Lan, Ju-Bao Zhang, Chang-Xing Qi, Yong-Hui Zhang
+1 more Yong-Hui Zhang
DOI: 10.1080/10286020.2025.2606379
Cited by: 0
References: 19

Abstract

Two undescribed alkaloids, mecichorine (1) and talaropyrazine D (2), along with four known compounds were isolated from an endophytic fungus Penicillium sp. HZ-5. Their structures were elucidated from the spectroscopic data. Furthermore, the isolated compounds were tested for their immunosuppressive activity, and compound 1 showed moderate immunosuppressive activity on Con A-induced T-lymphocyte proliferation in vitro, with an IC50 value of 15.2 ± 0.3 µM, and the others showed no obvious activities up to 40 µM.

Fields of Study & Subjects

Microbial Natural Products and Biosynthesis Plant and fungal interactions Fungal Biology and Applications

Publication details

Journal / source
Journal of Asian Natural Products Research
Volume
28
Issue
10
Pages
1466–1471
Publication date
10 January 2026
Language
EN