Immunohistochemical and metabolomic analysis of Tibetan medicine triphala in response to pancreatic tissues of diabetic rats

Journal of Asian Natural Products Research 2026

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Authors: Xue-Yan Li, Xiao‐mei Long, Tao Liu, Shuang Guo, Jianxing Gu, Fangfang Chen, Yi-dan Fan, Yi-dan Fan, Haipeng Liu, Yuan Fan, Yuan Fan, Zhu-Sheng Tang
DOI: 10.1080/10286020.2025.2607494
Cited by: 0
References: 24

Abstract

Tibetan Medicine Triphala (THL), consisting of Emblica officinalis, Terminalia bellerica, and Terminalia chebula, is a traditional Tibetan remedy for diabetes mellitus (DM). This study investigated THL's pancreatic metabolomic effects and impacts on paracrine factors (glucagon, insulin, somatostatin, pancreatic polypeptide) in diabetic rats. Rats were divided into six groups, gavaged for 8 weeks, with weekly blood glucose/body weight monitoring. THL reduced serum glucagon, somatostatin, pancreatic polypeptide, elevated insulin, restored pancreatic β-cell function, downregulated α/δ/pp cell expressions, normalized 5 key differential metabolites, and modulated four core metabolic pathways, exerting antidiabetic effects.

Fields of Study & Subjects

Phytochemicals and Medicinal Plants Natural Antidiabetic Agents Studies Medicinal Plants and Neuroprotection

Publication details

Journal / source
Journal of Asian Natural Products Research
Volume
28
Issue
10
Pages
1495–1513
Publication date
6 January 2026
Language
EN