New alkaloids from the twigs and leaves of tabernaemontana divaricata and their neuroprotective effects

Journal of Asian Natural Products Research 2026

View at publisher
Authors: Danyi Lu, Fei-Yan Wu, Nan Zhou, Xia Zhang, Xia Zhang, Zhenhua Li, Zhenhua Li, Song Wang, Min Ju Song, Zi-Wei Li, Zi-Wei Li, Xiao-Qi Zhang
+1 more Xiao-Qi Zhang
DOI: 10.1080/10286020.2025.2608814
Cited by: 0
References: 22

Abstract

Two novel monoterpenoid quinoline alkaloids, tabernacatines A and B (1 and 2), and a new monoterpenoid indole alkaloid, tabernacatine C (3), along with three known alkaloids (4 − 6), were isolated from the twigs and leaves of Tabernaemontana divaricata. Their structures were elucidated based on UV, IR, HR-ESI-MS, NMR spectra analysis, X-ray diffraction, and ECD calculation methods. Compounds 1 − 6 were evaluated for their neuroprotective effects in glutamate-induced HT22 cells, and compounds 4–6 exhibited potent neuroprotective effects.

Fields of Study & Subjects

Alkaloids: synthesis and pharmacology Berberine and alkaloids research Magnolia and Illicium research

Publication details

Journal / source
Journal of Asian Natural Products Research
Pages
1–9
Publication date
6 January 2026
Language
EN