Methyl jasmonate protects liver and pancreas tissues of adult diabetic rats from STZ-induced oxidative stress damage
Abstract
This study evaluated the potential of methyl jasmonate (MeJA) to modulate oxidative stress damage and hyperglycemia in rats with STZ-induced diabetes. MeJA treatment (5 and 10 mg/kg) improved the destructive effects of STZ-induced oxidative damage, as proved by the decline in ROS formation and lipid peroxidation. In addition, MeJA displayed a substantial upsurge in the level of tissue GSH and activity of CAT and SOD enzymes. Histological analysis confirmed MeJA alleviated liver damage. Given the crucial part oxidative stress plays in the etiology of diabetes, this study offers a novel viewpoint on MeJA's potential as a treatment.
Fields of Study & Subjects
Natural Antidiabetic Agents Studies
Antioxidant Activity and Oxidative Stress
Genomics
phytochemicals
and oxidative stress
Publication details
- Journal / source
- Journal of Asian Natural Products Research
- Volume
- 28
- Issue
- 10
- Pages
- 1538–1552
- Publication date
- 12 January 2026
- Language
- EN