A new nor-28-oleanane glycoside isolated from Syzygium formosum inhibits nitric oxide production in LPS-stimulated RAW264.7 cells

Journal of Asian Natural Products Research 2026

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Authors: Pham Thi Tham, Pham Thi Thu Giang, Đàm Xuân Thắng, Vũ Thị Thu Hòa, Ngo Thuy Van, Do Thu Chieu, Dao Duy Manh, Phạm Thế Chính, Bùi Hữu Tài, Phan Văn Kiệm
DOI: 10.1080/10286020.2026.2615673
Cited by: 0
References: 26

Abstract

One new nor-28-oleanane glycoside (1) and fifteen known compounds (2 − 16) were separated from a methanol extract of Syzygium formosum leaves. Their structures were elucidated via HRESIMS and NMR spectroscopic analyses. The absolute configuration of 1 was determined based on ECD spectra calculated using TD-DFT methods. Among the isolates, syringin (11) exhibited significant inhibitory activity against NO production in LPS-stimulated RAW264.7 cells, with an IC50 value of 18.4 μM. Compounds 1 − 3 displayed moderate inhibitory effects, with IC50 values of 58.4–79.2 μM.

Fields of Study & Subjects

Natural product bioactivities and synthesis Phytochemistry and Biological Activities Phytochemical Studies and Bioactivities

Publication details

Journal / source
Journal of Asian Natural Products Research
Volume
28
Issue
10
Pages
1566–1574
Publication date
19 January 2026
Language
EN