The importance of nitrile functionality: FDA-approved small molecules from 2021 to 2024
Abstract
Nitrile-containing drugs represent an important class of natural and pharmaceutical compounds, exhibiting diverse biological activities across multiple therapeutic areas. The incorporation of a nitrile functional group in drug molecules influences their pharmacokinetic properties, bioavailability, and metabolic stability. This review provides a comprehensive analysis of the role of nitrile groups in drug design, their pharmacological significance, and the key synthetic strategies used for the development of the eleven FDA-approved nitrile-containing drugs from 2021 to 2024.
Fields of Study & Subjects
Chemical Reactions and Isotopes
Chemical Reaction Mechanisms
Pharmacological Receptor Mechanisms and Effects
Publication details
- Journal / source
- Phosphorus, sulfur, and silicon and the related elements
- Publisher
- Informa UK Limited
- Volume
- 201
- Issue
- 4
- Pages
- 376–394
- Publication date
- 1 January 2026
- Language
- EN