Real-world venetoclax dosing patterns and treatment persistence in patients with acute myeloid leukemia: a community pharmacy database study in Japan
Abstract
= 162) were clustered by mean daily VEN dose and dosing frequency, yielding four groups defined by high versus low dose and high versus low frequency. Treatment persistence was longer in the low-frequency clusters, where there was a clearer association with dosing frequency than with mean daily dose. Strong CYP3A4 inhibitor use was more common in low-dose clusters, consistent with dose adjustment when strong inhibitors are coadministered. These findings highlight heterogeneous real-world VEN use and its implications for treatment persistence.
Fields of Study & Subjects
Acute Myeloid Leukemia Research
Acute Lymphoblastic Leukemia research
Retinoids in leukemia and cellular processes
Publication details
- Journal / source
- Leukemia & lymphoma/Leukemia and lymphoma
- Publisher
- Informa UK Limited
- Volume
- 67
- Issue
- 8
- Pages
- 1788–1795
- Publication date
- 22 May 2026
- Language
- EN