Advanced maternal age is a risk factor for both early-onset and late-onset hypertensive disorders of pregnancy: the Japan environment and children’s study

Hypertension in Pregnancy 2026 Open access

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Authors: Kazuma Tagami, Hasumi Tomita, Noriyuki Iwama, Hirotaka Hamada, Natsumi Kumagai, Hongxin Wang, Seiya Izumi, Zen Watanabe, Mami Ishikuro, Taku Obara, Hirohito Metoki, Yuichiro Miura
+6 more Chiharu Ota, Shinichi Kuriyama, Takahiro Arima, Nobuo Yaegashi, M. SAITO, The Japan Environment and Children’s Study Group
DOI: 10.1080/10641955.2026.2634181
Cited by: 2
References: 44

Abstract

OBJECTIVE: Advanced maternal age (AMA, ≥35 years), particularly prevalent in Japan, is associated with adverse perinatal outcomes, including hypertensive disorders of pregnancy (HDP), which vary in severity based on the timing of onset (early-onset and late-onset). This study aimed to investigate the association between maternal age and early-onset and late-onset HDP. METHODS: A total of 80,872 pregnant women were included in this prospective birth cohort study. Associations between maternal age and early-onset, preterm late-onset, and term late-onset HDP were evaluated using a multinomial logistic regression model adjusted for potential confounding factors. Maternal age was categorized into five:

Fields of Study & Subjects

Pregnancy and preeclampsia studies Birth Development and Health Gestational Diabetes Research and Management

Publication details

Journal / source
Hypertension in Pregnancy
Publisher
Informa UK Limited
Volume
45
Issue
1
Pages
2634181–2634181
Publication date
10 March 2026
Language
EN